PPH
Effective, non-cell permeable and non-toxic spin probe for detection of extracellular
in vitro and in vivo and mitochondrial production of ROS (O2-, ONOO-). Resistant
against reduction of vitamin C or thiols. Half-life time of spin adduct in biological
environment amount to 4h. Samples in frozen condition (-80 °C or liquid nitrogen)
can be stored up to 6 months.

Rerferences

1. Panov A. et al., Rotenone model of Parkinson disease: multiple brain mitochondria dysfunctions after short term systemic rotenone intoxication. J Biol Chem.: 2005, 280: 42026-35 (PDF)
2. Dikalova A. et al., Noninvasive diagnostic tool for inflammation-induced oxidative stress using electron spin resonance spectroscopy and an extracellular cyclic hydroxylamine. Arch Biochem Biophys: 2002; 15;402:218-26. (PDF)
3. Fink B. et al., A new approach for extracellular spin trapping of nitroglycerin-induced superoxide radicals both in vitro and in vivo. Free Radic Biol Med. 2000 Jan 1;28(1):121-8. (PDF)