DF
An iron chelator used often in the studies of cell proliferation and apoptosis.
Induces apoptosis in cells by chelating iron. After 48 hrs treatment with 1 μ M
deferoxamine, DNA fragmentation was apparent. Cells treated with 0.1 μM
deferoxamine for as little as 24 hours were committed to apoptosis; by 48 hrs
nuclear collapse was observed. In some studies it has been shown to have
antioxidant properties and to protect cells against H₂O₂-induced damage.

Rerferences

1. Porreca, E., et al., Antiproliferative effect of desferrioxamine on vascular smooth muscle cells in vitro and in vivo . Arterioscler. Thromb. 14 , 299-304, (1994) (Abstract)
2. Fukuchi, K., et al., DNA damage induces p21 protein expression by inhibiting ubiquitination in ML-1 cells. Biochim. Biophys. Acta 1404 , 405-411, (1998) (Abstract)
3. Chenoufi, N., et al., Deferoxamine arrests in vitro the proliferation of porcine hepatocyte in G1phase of the cell cycle. Liver 18 , 60-66, (1998) (Abstract)
4. An, W.G., et al., Stabilization of wild-type p53 by hypoxia-inducible factor 1α. Nature 392 , 405-408, (1998) (Abstract)