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Role of free Radicals
Cardiovascular Disease
Cardiovascular disease is the single largest cause of mortality in the population. Cardiovascular disease is a global term used for a range of diseases, which include ischemic heart disease (IHD), cerebrovascular disease (CVD), and other related diseases, for example myocardial infarction (MI). Excess free radicals are thought to initiate atheroscelerosis by damaging blood vessel walls. LDL-cholesterol has long been implicated in the development of heart disease and many clinicians report that lowering blood cholesterol is the most effective means of combating heart disease. However, LDL only poses a threat after oxidation by free radicals, as it is reported to migrate across the endothelial membrane into the arterial wall. These oxidized components attract macrophages, which absorb and deposit cholesterol within the cell to form what has been referred to as “foam cells”. These foam cells may initiate the formation of an atherosclerotic lesion, which can result in blockage of blood vessels. Interruption of the blood supply causes severe pain, known as angina pectoris, and may eventually cause death of the cardiac tissue
Several epidemiological studies have shown a reduction in cardiovascular disease in individuals supplemented with antioxidants. The “Nurses, Health Study” was undertaken to asses the effects of vitamin intake on the incidence of coronary heart disease. The dietary habits of 87.245 female nurses were examined and involved an eight year follow up with 552 major cases of coronary heart disease, including 115 fatal and 437 non-fatal cases and 183 cases of ischemic stroke. Results showed that increased intake of vitamin E and ß-carotene reduced the incidence of coronary heart disease.
ReferencesEl-Gebali HH. Tahir SA. Haider SS. El-Fakhri MM. Lipid peroxidative damage in the erythrocytes and elevation of serum LDL-cholesterol, apolipoprotein-B, ferritin and uric acid with age and in coronary heart disease patients. Saudi Medical Journal. 21(2):184-9, 2000
Duffy SJ. Biegelsen ES. Holbrook M. Russell JD. Gokce N. Keaney JF Jr. Vita JA. Iron chelation improves endothelial function in patients with coronary artery disease. Circulation. 103(23):2799-804, 2001 Jun 12.
Maxwell SR. Coronary artery disease--free radical damage, antioxidant protection and the role of homocysteine. Basic Research in Cardiology. 95 Suppl 1:I65-71, 2000.
Duilio C. Ambrosio G. Kuppusamy P. DiPaula A. Becker LC. Zweier JL. Neutrophils are primary source of O2 radicals during reperfusion after prolonged myocardial ischemia. American Journal of Physiology - Heart & Circulatory Physiology. 280(6):H2649-57, 2001
Landmesser U. Merten R. Spiekermann S. Buttner K. Drexler H. Hornig B. Vascular extracellular superoxide dismutase activity in patients with coronary artery disease: relation to endothelium-dependent vasodilation. Circulation. 101(19):2264-70, 2000
Lefer DJ. Granger DN. Oxidative stress and cardiac disease. American Journal of Medicine. 109(4):315-23, 2000
Konuralp C. Guner S. Cakatay U. Konuralp Z. Yapici N. Macika H. Aydogan H. Aykut-Aka S. Alhan C. Gultepe M. Eren EE. Effect of partial oxygen supply on mitochondrial electron transport system during complete cardiac ischemia. Journal of Cardiac Surgery. 14(6):424-34; discussion 435-6, 1999
Yokoyama M. Inoue N. Kawashima S. Role of the vascular NADH/NADPH oxidase system in atherosclerosis. Annals of the New York Academy of Sciences. 902:241-7; discussion 247-8, 2000
Giannitsis E. Tettenborn I. Wiegand U. Stierle U. Katus HA. Soluble L-selectin and neutrophil derived oxidative stress after pacing induced myocardial ischemia in chronic stable coronary artery disease. Pacing & Clinical Electrophysiology. 23(3):309-14, 2000
Kojda G. Harrison D. Interactions between NO and reactive oxygen species: pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure. Cardiovascular Research. 43(3):562-71, 1999
Aminbakhsh A. Mancini J. Chronic antioxidant use and changes in endothelial dysfunction: a review of clinical investigations. Canadian Journal of Cardiology. 15(8):895-903, 1999
Speir E. Yu ZX. Ferrans VJ. Infectious agents in coronary artery disease: viral infection, aspirin, and gene expression in human coronary smooth muscle cells. Revista Portuguesa de Cardiologia. 17 Suppl 2:II33-9, 1998
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